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How to make the complete record as read only??

Hi All,


I have a custom object, I need to make the record as read only based on the value of a particular custom picklist field..for a particular profile...


For Ex:


I have an Object says: Custom_Object__c

Custom Field is: Picklist__c


as i save the record with the Picklist__c='Changed' for a particular profile.. my complete record should become read only.. is that can be achieved...?