Following Red lins are not covered

public with sharing class TestFlighRequestPage {
Test_Flight_Request__c fr;
public String Id {get; set;}
private String result;
public static boolean isApexTest = false;
public TestFlighRequestPage(ApexPages.StandardController stdController)
{
fr = (Test_Flight_Request__c)stdController.getRecord();

Id = fr.Opportunity__c;
}

public PageReference Save()
{
update fr;
PageReference pr = new PageReference('/'+ Id);
pr.setRedirect(true);
return pr;
}

public void SendItineryEmail()
{
Test_Flight_Request__c FRdata = [SELECT Email_To__c, Email_Content__c,Subject__c
FROM Test_Flight_Request__c WHERE Id = :fr.Id];

Http h = new Http();
HttpRequest req = new HttpRequest();
req.setEndpoint('http://testsite.com/GetCustomerView?opportunityId='+fr.Opportunity__c+'&flightRequestID='+fr.Id);
req.setMethod('GET');

HttpResponse res = h.send(req);
result = res.getBody();
String[] toaddress = new String[]{};
toaddress.add(FRdata.Email_To__c);
Messaging.SingleEmailMessage mail = new Messaging.SingleEmailMessage();
mail.setToAddresses(toaddress);
string EmailSubject ='';
if(FRdata.Subject__c !=null)
{
EmailSubject = FRdata.Subject__c;
}
else
{
EmailSubject ='Flight stat';
}
mail.setSubject(EmailSubject);
string emaildata='';
if(FRdata.Email_Content__c != null)
{
emaildata = FRdata.Email_Content__c + '<br>' + result;
}
else
{
emaildata = result;
}

mail.setHtmlBody(emaildata);
Messaging.sendEmail(new Messaging.SingleEmailMessage[] { mail });
}

public void TestCloneFlightRequest()
{
isApexTest = true;
CloneFlightRequest();
}


public PageReference CloneFlightRequest()
{
Test_Flight_Request__c clFR = new Test_Flight_Request__c();
Test_Flight_Request__c oldFR = [SELECT From__c, To__c,Outbound_del__c,Pax_del__c,Region_del__c,
Inbound_del__c,Outbound_Flexibility__c,Inbound_Flexibility__c,Opportunity__c,
Budget__c,Flight_Request_Type__c,Publish_Fare__c,Searcher__c,Notes__c,Email_To__c,Email_Content__c,
Subject__c,Status__c,Miles__c,Internal_Flight__c,Approx_Tax__c,Searcher_Notes__c,Field1__c
FROM Test_Flight_Request__c WHERE Id = :fr.Id];

clFR.From__c = oldFR.From__c;
clFR.To__c = oldFR.To__c;
clFR.Outbound_del__c = oldFR.Outbound_del__c;
clFR.Pax_del__c = oldFR.Pax_del__c;
clFR.Region_del__c = oldFR.Region_del__c;
clFR.Inbound_del__c = oldFR.Inbound_del__c;
clFR.Outbound_Flexibility__c = oldFR.Outbound_Flexibility__c;
clFR.Inbound_Flexibility__c = oldFR.Inbound_Flexibility__c;
clFR.Opportunity__c = oldFR.Opportunity__c;
clFR.Budget__c = oldFR.Budget__c;
clFR.Publish_Fare__c = oldFR.Publish_Fare__c;
clFR.Flight_Request_Type__c = oldFR.Flight_Request_Type__c;
clFR.Notes__c = oldFR.Notes__c;

clFR.Searcher__c = oldFR.Searcher__c;

clFR.Email_To__c = oldFR.Email_To__c;
clFR.Email_Content__c = oldFR.Email_Content__c;
clFR.Subject__c = oldFR.Subject__c;

clFR.Status__c = oldFR.Status__c;
clFR.Miles__c = oldFR.Miles__c;
clFR.Internal_Flight__c = oldFR.Internal_Flight__c;
clFR.Approx_Tax__c = oldFR.Approx_Tax__c;
clFR.Searcher_Notes__c = oldFR.Searcher_Notes__c;
clFR.Field1__c = oldFR.Field1__c;
insert clFR;
System.debug('Old FRId:'+oldFR.Id);
System.debug('New FRId:'+clFR.Id);

if(!isApexTest)
{
CloneMethod(ID,oldFR.Id,clFR.Id);
}
else
{
System.debug('Salesforce');
}
PageReference pr = new PageReference('/'+ Id);
pr.setRedirect(true);
return pr;
}

@Future(callout=true)
public static void CloneMethod(string fid, string oldid,string newid)
{
Http h = new Http();
HttpRequest httpreq = new HttpRequest();
httpreq.setEndpoint('http://testsite.com/ibb/CloneFlightData?opportunityId='+fid+'&oldFlightRequestID='+oldid+'&newFlightRequestID='+newid);
httpreq.setMethod('GET');
httpreq.setTimeout(60000);

HttpResponse res = h.send(httpreq);
}
}

Here is the Test case

@isTest
private class TestFlighRequestPageTestCase {

static testMethod void myUnitTest() {
Test_Flight_Request__c fr;
List<Opportunity> listOpp;
String Id ;
String result;
boolean isApexTest = true;

Opportunity opp = new Opportunity();
opp.Name = 'Test Opp';
opp.StageName = 'Ticketing';
opp.p1_First_Name__c ='A';
opp.p1_Last_Name__c ='D';
opp.p1_Gender__c = 'S';
opp.p1_First_Name__c ='S';
opp.p1_Last_Name__c ='A';
opp.p1_Gender__c = 'D';
opp.DOB_Main_Passenger__c = System.now().date();
opp.Number_of_Passengers__c = 4;
opp.CloseDate = System.now().date();
opp.Departure_Date__c = System.now().date();
opp.Origin_City__c = 'DEL';
opp.Destination_City__c= 'MUI';
opp.Return_Date__c = System.now().date();
insert opp;

fr = new Test_Flight_Request__c();
fr.Budget__c = '23';
fr.Publish_Fare__c = '35';
fr.Opportunity__c = opp.Id;
fr.From__c = opp.Origin_City__c;
fr.To__c = opp.Destination_City__c;
fr.Outbound_del__c = opp.Departure_Date__c;
fr.Pax_del__c = opp.Number_of_Passengers__c;
fr.Region_del__c = opp.Destination_Zone__c;
fr.Inbound_del__c = opp.Return_Date__c;
fr.Outbound_Flexibility__c = opp.Flexibility_From__c;
fr.Inbound_Flexibility__c = opp.Flexibility_To__c;
fr.Email_To__c ='anil@swiftsetup.com';
fr.Email_Content__c= 'Test';
fr.Subject__c ='subject test';

insert fr;



ApexPages.StandardController sc = new ApexPages.StandardController(fr);
TestFlighRequestPage sc1 = new TestFlighRequestPage(sc);
sc1.Save();
sc1.TestCloneFlightRequest();
sc1.SendItineryEmail();
update fr;




}
}

The way I'd normally handle this is to only carry out the callout if not in test mode, but if it is in test mode, fake a response that the rest of the code can process.

i think i did same

using isApexTest = true

is set it to not call CloneMethod() from Test case which send request

Please Let me know if i m doing wrong?

when followed this

http://sfdc.arrowpointe.com/2009/05/01/testing-http-callouts/

getting same error  "System.CalloutException: . Please commit or rollback before calling out"

You shouldn't need ifApexTest=true - use the platform version to check if you are in the test context.